This was exactly the situation when we analyzed 5 different samples of lactose for a global pharma company in Basel, Switzerland, without knowing anything about the use and the performance of the individual samples of lactose. The 5 powder samples were analyzed by a method called Inverse Gas Chromatography or just IGC, which is able to identify tiny differences in surface properties by dynamic pulse adsorption of 15 or more different gases.
One sample clearly stood out in terms of surface accessibility (measured by branched, cyclic and linear alkanes), polarity and acid-base properties (measured by different polar molecules). As it turned out, this was the “good” sample with excellent dissolution behavior – and from the old production. The other samples were clearly differentiated by IGC and their application behaviors were around borderline. IGC data provided not only a clear indication which samples were “good” and “bad”, but also a unique indication, why the samples behaved differently and how the lactose and its surface properties might be optimized.
IGC is a powerful technique to characterize surface properties of any powders, particles and fibers. Adscientis SARL and Inolytix Ltd provide an outstanding service lab not only to characterize your samples, but also to provide interpretation and understanding. And soon, together with Porotec, we are just launching a powerful, new IGC instrument to facilitate also your in-house IGC analysis.
Do you have comparable problems? The 6th International IGC Symposium, June 20th, 2017, Cologne, brings together experts from BASF, Kronos, Fraunhofer and more. Or just write an email (firstname.lastname@example.org) or take the phone (+41 79 312 9327).
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